Catabolism of Glucose in Glycolysis and Pyruvate Oxidation

The first step of carbohydrate catabolism is glycolysis which produces pyruvate NADH and ATP. After a 3-week fast a marked reduction in glucose metabolism throughout the brain is observed using positron emission tomography.

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Glucose uptake of the brain is more than.

. ART FOR SCIENCE Getty Images. The citric acid cycle also known as the Krebs cycle or tricarboxylic acid TCA cycle is a series of chemical reactions in the cell that breaks down food molecules into carbon dioxide water and energyIn plants and animals eukaryotes these reactions take. The citric acid cycle occurs in the cristae or membrane folds of mitochondria.

These ATPs are supplied from fatty acid catabolism via beta oxidation. As fatty acid oxidation and ketone body formation increase there is a reduction in glucose production and oxidation mediated by downregulation of the pyruvate dehydrogenase complex activity. These enzymes are typically regulated by similar molecules but with opposite results.

Phosphofructokinase and pyruvate kinase enzymes of glycolysis are replaced with glucose-6-phosphatase fructose-16-bisphosphatase and PEP carboxykinasepyruvate carboxylase. In the cells glucose a six-carbon sugar is processed through a sequence of reactions into smaller sugars and the energy stored inside the molecule is released. Under anaerobic conditions the pyruvate can be converted into lactate to keep.

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